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Molecular mechanism of IgE-mediated FcεRI activation. Chen M, Su Q, Shi Y. Nature. 2025 Jan 9;637(8045):453–460.
Read-write mechanisms of H2A ubiquitination by Polycomb repressive complex 1. López VG, Valencia-Sánchez MI et al. Nature. 2024 Dec 19;636(8043):755–761.
Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma. Chen YJ, Iyer SV et al. Nature. 2024 Dec 12;636(8042):466-473.
Active-reset protein sensors enable continuous in vivo monitoring of inflammation. Zargartalebi H, Mirzaie S et al. Science. 2024 Dec 6;386(6726):1146-1153.
DMSO might impact ligand binding, capsid stability, and RNA interaction in viral preparations. Wald J, Goessweiner-Mohr N et al. Sci Rep. 2024 Dec 6;14(1):30408.
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October 14, 2024
Planned downtime: The Chimera and ChimeraX websites, web services (Blast Protein, Modeller, ...) and cgl.ucsf.edu e-mail will be unavailable starting Monday, Oct 14 10 AM PDT, continuing throughout the week and potentially the weekend (Oct 14-20).
August 1, 2024
Planned downtime: The Chimera and ChimeraX websites, web services (Blast Protein, Modeller, ...) and cgl.ucsf.edu e-mail will be unavailable August 1, 3-6 pm PDT.
July 16, 2024
Chimera production release 1.18 is now available. See the release notes for details.
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UCSF Chimera is a program for the interactive visualization and analysis of molecular structures and related data, including density maps, trajectories, and sequence alignments. It is available free of charge for noncommercial use. Commercial users, please see Chimera commercial licensing.
We encourage Chimera users to try ChimeraX for much better performance with large structures, as well as other major advantages and completely new features in addition to nearly all the capabilities of Chimera (details...).
Chimera is no longer under active development. Chimera development was supported by a grant from the National Institutes of Health (P41-GM103311) that ended in 2018.
Feature Highlight
The default ribbon path is a smooth bspline (semitransparent tan in the figure), which can diverge from the true positions of the backbone atoms (α-carbons shown as gray balls). A cardinal spline allows tracking the backbone more closely. Without smoothing (light blue), it follows the α-carbons exactly, or it can be combined with some “compromise” smoothing of strand and/or coil. Ribbon spline options can be set with the ribspline command or in the molecule model attributes.
(More features...)Gallery Sample
Peroxiredoxins are enzymes that help cells cope with stressors such as high levels of reactive oxygen species. The image shows a decameric peroxiredoxin from human red blood cells (Protein Data Bank entry 1qmv), styled as a holiday wreath.
See also the RBVI holiday card gallery.
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