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Structural basis of mRNA decay by the human exosome-ribosome supercomplex. Kögel A, Keidel A et al. Nature. 2024 Nov 7;635(8037):237-242.

Brain malformations and seizures by impaired chaperonin function of TRiC. Kraft F, Rodriguez-Aliaga P et al. Science. 2024 Nov 1;386(6721):516-525.

REliable PIcking by Consensus (REPIC): a consensus methodology for harnessing multiple cryo-EM particle pickers. Cameron CJF, Seager SJH et al. Commun Biol. 2024 Oct 31;7(1):1421.

Small molecule assembly agonist alters the dynamics of hepatitis B virus core protein dimer and capsid. Kant R, Lee LS et al. J Am Chem Soc. 2024 Oct 23;146(42):28856-28865.

Mechanism of bacterial predation via ixotrophy. Lien YW, Amendola D et al. Science. 2024 Oct 18;386(6719):eadp0614.

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News

October 14, 2024

Planned downtime: The Chimera and ChimeraX websites, web services (Blast Protein, Modeller, ...) and cgl.ucsf.edu e-mail will be unavailable starting Monday, Oct 14 10 AM PDT, continuing throughout the week and potentially the weekend (Oct 14-20).

August 1, 2024

Planned downtime: The Chimera and ChimeraX websites, web services (Blast Protein, Modeller, ...) and cgl.ucsf.edu e-mail will be unavailable August 1, 3-6 pm PDT.

July 16, 2024

Chimera production release 1.18 is now available. See the release notes for details.

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Upcoming Events

Please note that UCSF Chimera is legacy software that is no longer being developed or supported. Users are strongly encouraged to try UCSF ChimeraX, which is under active development.

UCSF Chimera is a program for the interactive visualization and analysis of molecular structures and related data, including density maps, trajectories, and sequence alignments. It is available free of charge for noncommercial use. Commercial users, please see Chimera commercial licensing.

We encourage Chimera users to try ChimeraX for much better performance with large structures, as well as other major advantages and completely new features in addition to nearly all the capabilities of Chimera (details...).

Chimera is no longer under active development. Chimera development was supported by a grant from the National Institutes of Health (P41-GM103311) that ended in 2018.

Feature Highlight

Interactive Shadows

Interactive shadows (shadows that move as structures are moved) can be enabled in the Effects dialog or with the command set shadows. Click the image to show a small molecule rotating above a rectangular plane. This simple animation was made with the Chimera command script tumble.com. Interactive shadows also work with ribbons, surfaces, and other representations.

(More features...)

Gallery Sample

Wasabi Receptor

The image shows the structure of the human TRPA1 ion channel (wasabi receptor) determined by electron cryo-microscopy, Protein Data Bank entry 3j9p. The four subunits of the tetramer are shown as ribbons in different colors over a dark-to-light gradient background. (More samples...)


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